| Movie | 13th Annual Prism Awards | Himself | 2017 |
| Movie | Quantum Quest: A Cassini Space Odyssey | Core | 2012-12-02 |
| Movie | The Captains | Himself | 2011-07-22 |
| Series | $#*! My Dad Says | Dr. Edison Milford Goodson III / ... | 2010-09-23 |
| Movie | Michael Jackson NRJ 12 Tribute | Himself | 2009-07-05 |
| Movie | The Wild | Kazar | 2006-04-14 |
| Movie | 'T4' Goes 'Over the Hedge' | Himself | 2006-07-01 |
| Movie | Over the Hedge | Ozzie | 2006-05-19 |
| Movie | How William Shatner Changed the World | Himself - Host / Narrator | 2005-11-13 |
| Movie | Lil' Pimp | Tony Gold | 2005-01-11 |
| Series | Boston Legal | Denny Crane | 2004-10-03 |
| Movie | 100 Greatest One Hit Wonders | Himself - Host | 2002-12-31 |
| Movie | Iron Chef USA: Showdown in Las Vegas | Chairman | 2001-11-16 |
| Movie | Trinity and Beyond: The Atomic Bomb Movie | Himself - Narrator | 1995-09-29 |
| Movie | Loaded Weapon 1 | General Mortars | 1993-02-05 |
| Movie | Hollywood on Horses | Himself | 1989-03-06 |
| Movie | North Beach and Rawhide | Rawhide MacGregor | 1985-11-12 |
| Series | T.J. Hooker | Sgt. T.J. Hooker / ... | 1982-03-13 |
| Movie | Airplane II: The Sequel | Murdock | 1982-12-10 |
| Movie | Visiting Hours | Gary Baylor | 1982-05-28 |
| Movie | Crash | Carl Tobias | 1978-10-29 |
| Movie | The Devil's Rain | Mark Preston | 1975-07-01 |
| Movie | Go Ask Alice | Sam | 1973-01-24 |
| Series | For the People | David Koster | 1965-01-31 |
| Series | Scope | None | 1954-12-19 |